Literature Review
Oct 27, 2010A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.
Manel et al identify a way for HIV-1 to elicit innate immunity in DCs, and propose that this innate response may be necessary for the effectiveness of an HIV-1 vaccine.
Contributed by Ralph Steinman, The Rockefeller University, New York, USA
Aug 24, 2010
Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders
A potential future sphere for vaccination would be to learn to induce T cells that suppress immunity.
Contributed by Mohammad Alam Miah, Sungkyunkwan University, Suwon, Korea
Aug 23, 2010
Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR
To improve vaccination with proteins, Klechevsky E. et al. evaluated human CD8+ T cell responses in culture after antigen targeting to dendritic cells (DCs) through different lectins, with emphasis on the ITIM containing DC immunoreceptor (DCIR).
Contributed by Leonia Bozzacco, The Rockefeller University, New York, USA
Aug 23, 2010
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
CD8+ T cell responses to vaccines can be improved throughcross-presentation.
Contributed by Gaëlle Breton, The Rockefeller University, New York, USA
Aug 23, 2010
Intranasal poly IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population
Synthetic double stranded RNA, such as poly ICLC, are being considered as adjuvants for vaccines.
Contributed by Marina Caskey, The Rockefeller University, New York, USA
Aug 23, 2010
CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-li
Lindsay et al assess innate mechanisms that allow recombinant Ad5 vectors (rAd5) to induce T cell immunity in mice.
Contributed by Christine Trumpfheller, The Rockefeller University, New York, USA
Aug 23, 2010
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components.
Strowig et al. report the first humanized mouse model to demonstrate a protective immune response, here control of EBV.
Contributed by Maggi Pack, The Rockefeller University, New York, USA
Jun 1, 2010
E-Cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.
One type of DC that has been studied mainly in tissue culture, rather than in vivo, is the monocyte-derived Dendritic cell (Mo-DC), but monocytes with features of DCs have been described during mouse models of infection such as listeria, leishmania, and influenza.
Contributed by Cheolho Cheong, The Rockefeller University, New York, USA
May 27, 2010
Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy.
To test the efficacy of DC based therapeutic vaccines, Routy et al. used autologous monocyte-derived DCs electroporated with amplified HIV RNAs from their own virus, including Gag, Vpr, Rev and Nef.
Contributed by Gaëlle Breton, The Rockefeller University, New York, USA
May 27, 2010
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.
The activation of innate immune responses by nucleic acids is a crucial initial step to protective and pathological immunity and is mediated by transmembrane Toll-like receptors (TLRs) and cytosolic receptors.
Contributed by Zhiqiang Zhang, MD Anderson Cancer Center, Houston, USA
May 27, 2010
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells.
Mouse CD8+ DCs are well known for their superior antigen cross-presentation activities.
Contributed by Musheng Bao, MD Anderson Cancer Center, Houston, USA
Apr 27, 2010
Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice.
This article describes a new vaccine candidate based on an auxotrophic Mycobacterium tuberculosis (Mtb) with a point mutation (ΔsecA), which affects bacterial virulence, and is recombinant for HIV Env or SIV Gag proteins.
Contributed by Pablo Donoso, and Pablo Muñoz, Pontificia Universidad Católica de Chile, Santiago, Chile
Apr 27, 2010
Seasonal influenza vaccine provides priming for A/H1N1 immunization
Epidemiological observations have suggested that elderly people are less prone to infection with the 2009 influenza A virus H1N1, but it is not yet clear whether this is due to a previous priming by seasonal influenza.
Contributed by Andrea Reboldi, Institute for Research in Biomedicine, Bellinzona, Switzerland
Apr 27, 2010
Dendritic cell mediated delivery of plasmid DNA encoding LAMP/HIV-1 Gag fusion immunogen enhances T cell epitope responses in HLA DR4 transgenic mice.
Vaccines based on HIV immunogens may not be effective in preventing natural infections because of the large number of genomic variants.
Contributed by Aniela Wozniak, Pontificia Universidad Católica de Chile, Santiago, Chile
Apr 27, 2010
Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity.
The route for vaccination represents an important parameter for vaccine efficacy.
Contributed by Hideki Ueno, Baylor Institute for Immunology Research, Dallas, USA
Apr 27, 2010
Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes.
Regulatory T (Treg) cells are not only required for the maintenance of immunological self-tolerance, they also can prevent effective anti-tumor immunity.
Contributed by Dirk Baumjohann, Institute for Research in Biomedicine, Bellinzona, Switzerland
Apr 27, 2010
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
Invariant natural killer T (iNKT) cells recognize glycolipids presented by CD1d, and then rapidly secrete large amounts of cytokines, such as IFN-γ and IL-4, and induce downstream activation of other cells, including DCs, NK cells, B cells, and T cells.
Contributed by Hideki Ueno, Baylor Institute for Immunology Research, Dallas, USA
Jan 1, 2010
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
Vulvar intraepithelial neoplasis is a chronic premalignant disorder caused by high-risk types of human papillomavirus (HPV), more than 75% involved HPV type 16 (HPV-16).
Contributed by Bei Wang, The Rockefeller University, New York, USA
Jan 1, 2010
CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help
CD4+ T cells are important players for priming and memory development of the cytotoxic CD8+ T lymphocyte (CTL) responses.
Contributed by Bei Wang, The Rockefeller University, New York, USA
Jan 1, 2010
T helper 17 cells promote cytotoxic T cell activation in tumor immunity
It is well known that T helper 1 cells provide critical helps to anti-tumor CD8 T cells.
Contributed by Bei Wang, The Rockefeller University, New York, USA
Jan 1, 2010
Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells
Toll-like receptor 9 (TLR9) is likely to play a role in the function of CpG oligos as adjuvants but signaling through TLR9 requires proteolytically cleavage.
Contributed by Bei Wang, The Rockefeller University, New York, USA
Jan 1, 2010
Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis
Atherosclerosis is a chronic inflammatory vascular disease but dendritic cell function needs to be explored.
Contributed by Jaehoon Choi, The Rockefeller University, New York, USA
Feb 23, 2009
Infection-mimicking materials to program dendritic cells in situ
This manuscript describes a new approach to dendritic cell based vaccines against cancer.
Contributed by Svetlana Mojsov, The Rockefeller University, New York, USA
